The history of weight loss and diabetes treatments is a fascinating tale of scientific discovery, human ingenuity, and the unyielding quest to tackle some of the most pervasive health challenges of our time. Over the centuries, societies have sought remedies for obesity, diabetes, and the complex interplay between the two—now commonly referred to as “diabesity.” This article explores the evolution of weight loss medications, the rise of diabesity, and how a venomous desert lizard, the Gila monster, inspired one of the most revolutionary diabetes and weight management drugs, Mounjaro.